Product Overview

DNase I is commonly used in mRNA manufacturing to digest the DNA template after in vitro transcription. Because it is added to the process and is not part of the final product, residual DNase I is a process-related impurity that has to be monitored and shown to be cleared. The DNase I ELISA Kit is designed for the quantitative detection of residual DNase I in the process workflows of mRNA vaccines, mRNA drugs, and other biological products. It uses the enzyme-linked immunosorbent assay (ELISA) format, which laboratories can run with standard plate-washing and plate-reading equipment. Sample handling is simple. The test sample does not need any special treatment. Users only verify suitability by choosing an appropriate dilution ratio, which confirms that the kit works for their particular sample matrix. The kit has few operating steps and is fast, with strong specificity and stable, reliable performance. This makes the kit a practical tool for process development, in-process control, and release testing of mRNA products, and for kit and reagent manufacturers that need residual enzyme testing alongside their products.

Product Features

• Quantitative detection of residual DNase I in mRNA process samples: The kit is designed for mRNA vaccines, mRNA drugs, and other biological product processes, where residual process enzymes need to be monitored.
• No special sample treatment required: Samples only need a suitable dilution, and suitability for your sample matrix is confirmed through dilution verification. This keeps sample preparation simple and reduces handling variability.
• Few steps, fast, specific, and stable: The operation has few steps and is fast, with strong specificity and stable, reliable performance for routine residual enzyme testing.

FAQ