Hyclate(24390-14-5)
Product Description
● Doxycycline Hcl is antibacterial spectrum is very close to Tetracycline and Terramycin, but it has better effect, be sensitive to the Staphylococcus Aureus of tetracycline-resistant, oxytetracycline, long lasting time.It is often used in Senile Chronic Bronchitis, respiratory tract infection, lung infection, acute tonsillitis, mycoplasma pneumonia, urinary tract infection, blood poisoning, bacillary dysentery, acute lymphadenitis, etc. It is very popular to Nephropathy patient because of its unobvious poisoning for kidney.
● Doxycycline Hyclate is the hyclate salt form of doxycycline, a synthetic, broad-spectrum tetracycline antibiotic exhibiting antimicrobial activity. Doxycycline hyclate binds reversibly to the 30S ribosomal subunit, possibly to the 50S ribosomal subunit as well, thereby blocking the binding of aminoacyl-tRNA to the mRNA-ribosome complex. This leads to an inhibition of protein synthesis. In addition, this agent has exhibited inhibition of collagenase activity.
Application
Doxycycline Hyclate is is used to treat a wide variety of bacterial infections, including those that cause acne. Doxycycline Hyclate is is also used to prevent malaria. Doxycycline Hyclate is is known as a tetracycline antibiotic. It works by stopping the growth of bacteria.This antibiotic treats only bacterial infections.
| Items | Specifications | Results |
| Appearance | Yellow crystalline powder | Conforms |
| Identification | TLC | Conforms |
| sulphuric acid reaction a yellow colour develops | Conforms | |
| it gives reaction of chlorides | Conforms | |
| PH | 2.0~3.0 | 2.3 |
| Specific absorbance | at 349nm e(1%) 300~355 | 320 |
| Specific optical rotation | -105 ~ -120° | -110° |
| Heavy metals: | ≤50ppm | < 20ppm |
| Light-absorbing impurities | at 490nm ≤0.07 | 0.03 |
| Related substances | 6-epidoxycycline ≤2.0%metacycline ≤2.0%
4-epidoxycycline ≤0.5% (ep5) 4-epi-6-epidoxycycline ≤0.5% (ep5) oxytetracycline ≤0.5% (ep5) any other impurity ≤0.5% not identified impurities ≤0.1% (ep5) |
1.6%0.1%
Not found Not found Not found Not found Not found |
| Ethanol | 4.3~6.0% (m/m) | 4.5% |
| Sulphated ash | ≤0.4% | 0.05% |
| Water | 1.4~2.8% | 1.8% |
| Assay | 95.0~102.0% ( c22h25cln2o8)based on anhydrous, ethanol-free substance | 98.6% |
| Conclusion | Conform with USP32 | |
