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  • Hyclate(24390-14-5)

Hyclate(24390-14-5)


CAS No.: 24390-14-5

MF: C22H24N2O8

Product Description

New Description

Product Description

● Doxycycline Hcl is antibacterial spectrum is very close to Tetracycline and Terramycin, but it has better effect, be sensitive to the Staphylococcus Aureus of tetracycline-resistant, oxytetracycline, long lasting time.It is often used in Senile Chronic Bronchitis, respiratory tract infection, lung infection, acute tonsillitis, mycoplasma pneumonia, urinary tract infection, blood poisoning, bacillary dysentery, acute lymphadenitis, etc. It is very popular to Nephropathy patient because of its unobvious poisoning for kidney.

● Doxycycline Hyclate is the hyclate salt form of doxycycline, a synthetic, broad-spectrum tetracycline antibiotic exhibiting antimicrobial activity. Doxycycline hyclate binds reversibly to the 30S ribosomal subunit, possibly to the 50S ribosomal subunit as well, thereby blocking the binding of aminoacyl-tRNA to the mRNA-ribosome complex. This leads to an inhibition of protein synthesis. In addition, this agent has exhibited inhibition of collagenase activity.

Application

Doxycycline Hyclate is is used to treat a wide variety of bacterial infections, including those that cause acne. Doxycycline Hyclate is is also used to prevent malaria. Doxycycline Hyclate is is known as a tetracycline antibiotic. It works by stopping the growth of bacteria.This antibiotic treats only bacterial infections.

Items Specifications Results
Appearance Yellow crystalline powder Conforms
Identification TLC Conforms
sulphuric acid reaction a yellow colour develops Conforms
it gives reaction of chlorides Conforms
PH 2.0~3.0 2.3
Specific absorbance at 349nm e(1%) 300~355 320
Specific optical rotation -105 ~ -120° -110°
Heavy metals: ≤50ppm < 20ppm
Light-absorbing impurities at 490nm ≤0.07 0.03
Related substances 6-epidoxycycline ≤2.0%metacycline ≤2.0%

4-epidoxycycline ≤0.5% (ep5)

4-epi-6-epidoxycycline ≤0.5% (ep5)

oxytetracycline ≤0.5% (ep5)

any other impurity ≤0.5%

not identified impurities ≤0.1% (ep5)

1.6%0.1%

Not found

Not found

Not found

Not found

Not found

Ethanol 4.3~6.0% (m/m) 4.5%
Sulphated ash ≤0.4% 0.05%
Water 1.4~2.8% 1.8%
Assay 95.0~102.0% ( c22h25cln2o8)based on anhydrous, ethanol-free substance 98.6%
Conclusion Conform with USP32

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