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  • Tranexamic Acid(1197-18-8)–Human API

Tranexamic Acid(1197-18-8)

CAS No.: 1197-18-8

EINECS No.: 356.2222

MF: C8H15NO2

Product Description

New Description

Product Description

● Tranexamic Acid(1197-18-8)

● CAS No.:·1197-18-8

● EINECS No.: 356.2222

● MF: C8H15NO2

● Package: 25Kg/Drum

● Tranexamic acid (TXA) is a medication used to treat or prevent excessive blood loss from major trauma, postpartum bleeding, surgery, tooth removal, nosebleeds, and heavy menstruation.[2][3] It is also used for hereditary angioedema.[2][4] It is taken either orally or by injection into a vein.

Mechanism of action

Tranexamic acid is a synthetic analog of the amino acid lysine. It serves as an antifibrinolytic by reversibly binding four to five lysine receptor sites on plasminogen. This decreases the conversion of plasminogen to plasmin, preventing fibrin degradation and preserving the framework of fibrin's matrix structure.Tranexamic acid has roughly eight times the antifibrinolytic activity of an older analogue, ε-aminocaproic acid.[citation needed] Tranexamic acid also directly inhibits the activity of plasmin with weak potency (IC50 = 87 mM),and it can block the active-site of urokinase plasminogen activator (uPA) with high specificity (Ki = 2 mM), one of the highest among all the serine proteases.

Tranexamic acid functions

Tranexamic acid is frequently used following major trauma.[13] Tranexamic acid is used to prevent and treat blood loss in a variety of situations, such as dental procedures, heavy menstrual bleeding, and surgeries with high risk of blood loss.

Items of Test Pharmacopeial Criteria Test Result
CHARACTERS Appearance: White or almost white, crystalline powder White crystalline powder
Solubility: Freely soluble in water and in glacial acetic acid, practically insoluble in acetone and in ethanol (96%) Pass
IDENTIFICATION Infrared Absorption Spectrophotometry: IR spectrum is in concordance with Tranexamic acid CRS Pass
TEST pH (2,2.3) 7.0 〜8.0 7.4
Related Substances (HPLC2.2.29) Impurity A≤ 0.1 % Not Detected
Impurity B≤ 0.2% 0.03%

Unspecified impurities≤ 0.10% Impurities D

Other Impurities



Not Detected

Sum of unspecified impurities≤ 0.2% 0.003%
Halides Expressed as Chlorides ≤140ppm <140ppm
Loss on Drying ≤0.5% 0.026%
Sulphated Ash ≤0.1% 0.027%
ASSAY Should be within (Dried based) 99.0% 〜101.0% 100.1%

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