Hydrochlorothiazide(125727-50-6)
Product Description
● Hydroxychlorothiazide hydrochloride is a diuretic, which can lower blood pressure and has diuretic effect, and is often used in combination with other antihypertensive drugs.
● Hydroxychlorothiazide hydrochloride is mainly indicated for cardiogenic edema, hepatogenic edema and renal edema: such as edema caused by nephrotic syndrome, acute glomerulonephritis, chronic renal failure and excess adrenocorticotropic hormone and estrogen; hypertension; and uremia. Appropriate potassium salt supplementation is advisable for long-term application.
| Test Items | Specifications | Result | |
| Appearance | White or almost white, crystalline powder. | White crystalline powder | |
| Solubility | Very slightly soluble in water, soluble in acetone, sparingly soluble in ethanol(96 per cent). It dissolve in dilute solutions of alkali hydroxides |
Conforms | |
| Identification | (1) Identification B (2) Identification A (3) Identification C (4) Identification D |
Conforms | |
| Acidity or alkalinity | <0.4ml | 0.36ml | |
| Related substances | Impurity A | <0.5% | 0.04% |
| Impurity B | <0.5% | 0.20% | |
| Impurity C | <0.5% | 0.05% | |
| Unspecified Impurity | <0.10% | <0.05% | |
| Total Impurities | <1.0% | 0.32% | |
| Chlorides | <100ppm | Conforms | |
| Loss on Drying | <0.5% | 0.08% | |
| Sulfated Ash | <0.1% | 0.02% | |
| Assay | 97.5% to 102.0%, on an anhydrous substance | 98.9% | |
| Additional items (In-house) | |||
| Residual Solvents | Methanol<3000ppm | ND | |
| Ethanol<5000ppm | ND | ||
| Formaldehyde | <15ppm | <15ppm | |
| MATERIAL IS FREE FROM FOREIGN PARTICLES | |||
| Packaging and storage: Keep in a well-closed container, protected firom light. |
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