Murine RNase inhibitor–Molecular diagnostics Featured Image
  • Murine RNase inhibitor–Molecular diagnostics
  • Murine RNase inhibitor–Molecular diagnostics

Murine RNase inhibitor

CAS no.: 14003-96-4

Package:2KU, 20KU,400KU

Product Detail


Murine RNase inhibitor is a recombinant murine RNase inhibitor expressed and purified from E.coli. It binds to RNase A, B or C in a 1:1  ratio through non-covalent bonding, thereby inhibiting the activity of the three enzymes and protecting RNA from degradation. However, It is noteffective against RNase 1, RNase T1, S1 Nuclease, RNase H or RNase from Aspergillus. Murine RNase inhibitor was tested by RT-PCR, RT-qPCR and IVT mRNA, and was compatible with various commercial Reverse transcriptases, DNA polymerases and RNA polymerases.

Compared to human RNase inhibitors, murine RNase inhibitor does not contain two cysteines that are highly sensitive to oxidation which causes inactivation of the inhibitor. That making it stable at low concentrations of DTT (less than 1 mM). This feature makes it suitable for use in reactions where high concentrations of DTT is adverse to the reaction (eg., Real-time RT-PCR)

Chemical structure

Chemical structure9


Test items


Enzyme Activity


Endonuclease Activity

None detected

Protein Purity


Exonulease Activity

None detected

Nicking Activity

None detected

Nickase Activity

None detected

E.coli DNA



Synthesis of the first strand of cDNA, RT-PCR, RT-qPCR, etc.

Protects RNA from degradation during in vitro transcription/translation (e.g., in vitro viral replication system).

Inhibition of RNase activity during RNA separation and purification.

Shipping and Storage

Transportation:  Ice packs

Storage Conditions: Store at -20 ℃,

Recommended re-test date: 2 years

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